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man-will-not-wait-giurgea

Nootropics are substances that enhance learning and memory, while being extremely safe and protective of the brain. The nootropic concept was coined by Corneliu Giurgea in 1972 to describe an entirely new type of substance called that did not fit into any existing classification.

Giurgea’s quote above captures the idea that our brains have not yet evolved to handle the much more complex world that we now live in and that we cannot wait passively for the brain to improve on its own. Nootropics help remove some of the limits that came about from humans evolving in this much different world.

Nootropic substances work in a number of different ways to enhance the brain’s abilities, such as increasing the supply of the precursors for the neurotransmitters needed to form memories (acetylcholine) and then increasing that neurotransmitter’s usage in the brain where memories are formed (hippocampus).1)Profound Effects of Combining Choline and Piracetam on Memory Enhancement and Cholinergic Function in Aged Rats

nootroo notropic

To be considered a nootropic, a substance must meet ALL of the following characteristics:

  1. Enhance learning and memory
  2. Have few side effects and extremely low toxicity
  3. Protect the brain from physical or chemical injury like concussions, barbiturates or scopolamine
  4. Enhance the firing mechanisms of neurons
  5. Prevent the disruption of learned behaviors and memory formation from conditions which tend to disrupt them, such as electroconvulsive shock or hypoxia.

*Amphetamines like Adderall and wakefulness-agents like Modafinil are NOT considered nootropics.

Nootroo is a once-daily capsule containing a blend of synergistic nootropics that enhances energy and focus for 6-8 hours and beyond. Nootroo was designed from the ground up to bring the purest, most powerful, and safest ingredients available, into a single capsule. With Nootroo’s commitment to being the Gold Standard in nootropics, you know you have the best.

Ingredients in Nootroo have been demonstrated to:

  • Increase verbal memory2)E. McGlade, A. Locatelli, J. Hardy, T. Kamiya, M. Morita, K. Morishita, Y. Sugimura and D. Yurgelun-Todd, “Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women,” Food and Nutrition Sciences, Vol. 3 No. 6, 2012, pp. 769-773
  • Increase attention for at least 6 hours3)PURENERGY: A Novel Next-Generation Caffeine Alternative White Paper
  • Increase physical endurance4)Determination of carphedon in human urine by solid-phase microextraction using capillary gas chromatography with nitrogen-phosphorus detection. Kim S1, Park JH, Myung SW, Lho DS.
  • Enhance synaptic transmission5)Noopept stimulates the expression of NGF and BDNF in rat hippocampus. Ostrovskaya RU, Gudasheva TA, Zaplina AP, Vahitova JV, Salimgareeva MH, Jamidanov RS, Seredenin SB.
  • Induce alpha-waves  in the prefrontal cortex6)L-theanine, a natural constituent in tea, and its effect on mental state. Nobre AC1, Rao A, Owen GN.
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Testimonials

“With Nootroo I’m able to stay in the zone all day and after work I have the energy to keep going.”

-Kostika S, 3D Modeler at Shapeways

“There is no better way to start your day than with a Nootroo.”

-Riva T,  Writer and Investor

“I definitely feel its effectiveness in my daily life, Nootroo is the real deal!”

-Vishal A., General Manager & Head of Sales, PHHHOTO

“After I took one this morning I was compelled to sight read classical Mozart for piano. It was so random and my skill was so effortless.”

-Jerilyn S, Musician and Technologist

“I’ve been taking it everyday and I’m feeling very sharp. I’ve also been able to cut back on my coffee consumption.”

-Chad F, CEO Fudali Apparel

“Wow! I didn’t think I would notice it, but I definitely am much more productive when taking Nootroo.”

-Jacquelyn A., Founder of Street Candy

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Ingredients and Instructions

Nootroo comes in two different formulas, a Gold formula and a Silver formula. The two formulas differ in the main ingredient. In the Gold is Noopept and in the Silver is Phenylpiracetam. Both then contain citicoline (Cognizin brand), L-theanine (Suntheanine brand), and a caffeine pterostilbene cocrystal (PURENERGY). The pills are alternated between, one day Gold, and the next day Silver. The Gold formula uses the naturally occurring flavonol, quercetin, to color the capsule yellow.

Noopept

Noopept has been shown in animal studies to be neuroprotective and to help to enhance and restore memory7)Ostrovskaya RU, Romanova GA, Barskov IV, Shanina EV, Gudasheva TA, Victorov IV, Voronina TA, Seredenin SB (1999). “Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model”. Behavioural Pharmacology 10 (5): 549–553.doi:10.1097/00008877-199909000-00013.PMID 10780261. In studies with the Alzheimer’s disease model, Noopept has restored spatial memory and increased immunoreactivity to amyloid buildup. 8)Ostrovskaya RU, Gruden MA, Bobkova NA, Sewell RD, Gudasheva TA, Samokhin AN, Seredinin SB, Noppe W, Sherstnev VV, Morozova-Roche LA (2007). “The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model”. Journal of Psychopharmacology 21 (6): 611–619.doi:10.1177/0269881106071335.  17092975.

Studies also show Noopept to stimulate the expression of Nerve Growth Factor (NGF) and Brain-Derived Neurotropic Factor (BDNF) in the hippocampus and cerebral cortex. The hippocampus is the region of the brain responsible for the formation of memories and consolidation of short-term memory to long-term memory. BDNF is a protein that is crucial in determining the quantity of new neurons the brain can create, as well as regulating growth, survival and, differentiation of existing neurons.9)” We showed that the nootropic drug increases expression of neurotrophic factors in the hippocampus. Our results are consistent with the hypothesis that neurotrophin synthesis in the hippocampus determines cognitive function, particularly in consolidation and delayed memory retrieval. Published data show that neurotrophic factor deficiency in the hippocampus is observed not only in advanced Alzheimer’s disease, but also at the stage of mild cognitive impairment (predisease state). In light of this our findings suggest that Noopept holds much promise to prevent the development of Alzheimer’s disease in patients with mild cognitive impairment. Moreover, therapeutic effectiveness of Noopept should be evaluated at the initial stage of Alzheimer’s disease.” http://link.springer.com/article/10.1007%2Fs10517-008-0297-x

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Phenylpiracetam

Phenylpiracetam is a nootropic substance that has been shown to improve cognition in persons with cognitive decline from organic causes.10)Lybzikova GN, Iaglova ZhS, Kharlamova IuS. The efficacy of phenotropil in the complex treatment of epilepsyZh Nevrol Psikhiatr Im S S Korsakova. (2008) It has also been shown to improve cognition in youth with epilepsy. In rodent trials Phenylpiracetam has been shown to improve retention latency by over 185%. 11)Zvejniece L, et alInvestigation into stereoselective pharmacological activity of phenotropilBasic Clin Pharmacol Toxicol.

A single dose of phenylpiracetam has been shown to cause a “significant increase in locomotor activity” and a ‘significantly enhanced memory function in a passive avoidance response test” in rodents. 12)Zvejniece L, et alInvestigation into stereoselective pharmacological activity of phenotropilBasic Clin Pharmacol Toxicol. (2011)

Phenylpiracetam has also been shown to be effective in increasing physical endurance, adaptation and resistance to cold. 13) “Carphedon is a phenyl derivative of nootropil and is effective in increasing physical endurance and cold resistance, and is used for amnesia treatment.” Analyst. 1999 Nov;124(11):1559-62. PMID: 10746314.

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The following ingredients are found in both the silver and gold capsules.

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Citicoline

Citicoline is a precursor for the memory neurotransmitter and supplementation has been shown to increase acetylcholine production in the brain. Studies in healthy women show that taking Cognizin citicoline their verbal memory after just 28 days. Studies suggest that citicoline also can help increase dopamine receptor densities 14)Giménez R, Raïch J, Aguilar J (November 1991).“Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice”British Journal of Pharmacology 104(3): 575–8. doi:10.1111/j.1476-5381.1991.tb12471.x.PMC 1908237PMID 1839138., which is the neurotransmitter associated with motivation. Citicoline has been shown to help improve focus and mental energy 15)“Supplement naturally boosts ageing brain power”Sydney Morning Herald. 2008-02-25. Retrieved 2009-07-28., as well as helping with the treatment of attention deficit disorder. 16)Silveri MM, Dikan J, Ross AJ, et al. (November 2008). “Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy”. NMR in Biomedicine 21 (10): 1066–75.doi:10.1002/nbm.1281PMID 18816480

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L-Theanine

L-theanine is an amino acid found in green teas and is well known for its ability to calm a person down without making them tired. 17)Kimura, Kenta; Ozeki, Makoto; Juneja, Lekh Raj; Ohira, Hideki (2007). “L-Theanine reduces psychological and physiological stress responses”. Biological Psychology 74 (1): 39–45.doi:10.1016/j.biopsycho.2006.06.006.PMID 16930802.. L-theanine has also been shown to improve cognition 18)Park, Sang-Ki; Jung, In-Chul; Lee, Won Kyung; Lee, Young Sun; Park, Hyoung Kook; Go, Hyo Jin; Kim, Kiseong; Lim, Nam Kyoo et al. (2011). “A Combination of Green Tea Extract andl-Theanine Improves Memory and Attention in Subjects with Mild Cognitive Impairment: A Double-Blind Placebo-Controlled Study”. Journal of Medicinal Food 14 (4): 334–43.doi:10.1089/jmf.2009.1374PMID 21303262. Theanine has also been shown to induce alpha waves in the prefrontal cortex, in a way that is similar to the waveform that appears during meditation.  While L-theanine works great on its own, when combined with caffeine, their synergistic relationship has been shown to boost mood and cognitive performance. 19)Park, Sang-Ki; Jung, In-Chul; Lee, Won Kyung; Lee, Young Sun; Park, Hyoung Kook; Go, Hyo Jin; Kim, Kiseong; Lim, Nam Kyoo et al. (2011). “A Combination of Green Tea Extract andl-Theanine Improves Memory and Attention in Subjects with Mild Cognitive Impairment: A Double-Blind Placebo-Controlled Study”. Journal of Medicinal Food 14 (4): 334–43.doi:10.1089/jmf.2009.1374PMID 2130326220)Haskell, Crystal F.; Kennedy, David O.; Milne, Anthea L.; Wesnes, Keith A.; Scholey, Andrew B. (2008). “The effects of l-theanine, caffeine and their combination on cognition and mood”. Biological Psychology 77 (2): 113–22.doi:10.1016/j.biopsycho.2007.09.008.PMID 18006208. 21)Raloff, Janet (September 29, 2007).“Distracted? Tea might help your focus”.Science News 172 (13): 206.doi:10.1002/scin.2007.5591721319. “John J. Foxe of the Nathan S. Kline Institute for Psychiatric Research in Orangeburg, N.Y., and his colleagues recruited 16 people for tests of attentiveness on four days. Before testing, each individual drank a glass of water. On 3 days, the drink was spiked with 100 milligrams of theanine, 60 mg of caffeine, or both. The theanine dose was equivalent to that in 4 to 5 cups of tea, and the caffeine translated to about 2.5 cups of tea. In the difficult tests, participants watched a computer screen and pressed a button when a designated shape appeared on the side of a busy visual field to which an arrow had previously pointed. Participants’ accuracy differed little between days when they got water alone or with only one additive. Accuracy improved dramatically, however, on the day that they got the theanine-caffeine combination. The attention benefit lasted throughout the 3 hours of testing.” 22)Owen, Gail N.; Parnell, Holly; De Bruin, Eveline A.; Rycroft, Jane A. (2008). “The combined effects of L-theanine and caffeine on cognitive performance and mood”. Nutritional Neuroscience 11 (4): 193–8.doi:10.1179/147683008X301513.PMID 18681988. 23)Einöther, Suzanne J.L.; Martens, Vanessa E.G.; Rycroft, Jane A.; De Bruin, Eveline A. (2010). “L-Theanine and caffeine improve task switching but not intersensory attention or subjective alertness”. Appetite 54 (2): 406–9.doi:10.1016/j.appet.2010.01.003.PMID 20079786. 24)Giesbrecht, T.; Rycroft, J.A.; Rowson, M.J.; De Bruin, E.A. (2010). “The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness”.Nutritional Neuroscience 13 (6): 283–90.doi:10.1179/147683010X12611460764840.PMID 21040626. 25)Kelly, Simon P.; Gomez-Ramirez, Manuel; Montesi, Jennifer L.; Foxe, John J. (2008). “L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance”The Journal of Nutrition 138 (8): 1572S–1577S. PMID 18641209.

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Caffeine Pterostilbene CoCrystal

PURENERGY is a next generation form of caffeine that provides a sustained energy boost over a significantly extended period of time while using less caffeine than a standard cup of coffee. This cocrystal form of caffeine has been shown to have statistical significance for fatigue and concentration after 6 hours, whereas normal caffeine lasts about 3 hours.

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References   [ + ]