phenylpiracetam-molecule-with-gold
Phenylpiracetam  is a nootropic substance that was developed in Russia in 1983 and is chemically related to and derived from Piracetam, but it is 30-60 times stronger.  A single dose of phenylpiracetam has been shown to cause a “significant increase in locomotor activity” and a ‘significantly enhanced memory function in a passive avoidance response test” in mammals. 1)Zvejniece L, et al. Investigation into stereoselective pharmacological activity of phenotropil. Basic Clin Pharmacol Toxicol. (2011 Phenylpiracetam has shown to be effective in increasing physical endurance, adaptation and resistance to cold. 2) “Carphedon is a phenyl derivative of nootropil and is effective in increasing physical endurance and cold resistance, and is used for amnesia treatment.” Analyst. 1999 Nov;124(11):1559-62. PMID: 10746314 For these reasons it has been banned by the International Olympic Committee (IOC) and World Anti-Doping Agency (WADA) in the stimulant category. Phenylpiracetam has been shown to improve cognition in persons with cognitive decline from organic causes. 3)Lybzikova GN, Iaglova ZhS, Kharlamova IuS. The efficacy of phenotropil in the complex treatment of epilepsy. Zh Nevrol Psikhiatr Im S S Korsakova. 2008 It has also been shown to improve cognition in youth with epilepsy. In animal trials Phenylpiracetam has been shown to improve retention latency by over 185%. 4)Zvejniece L, et al. Investigation into stereoselective pharmacological activity of phenotropil. Basic Clin Pharmacol Toxicol. Memory, Cognition, Attention, Depression

In 2003, the State Pharmacological Committee of Russia approved phenylpiracetam for cerebrovascular deficiency, depression, apathy, attention and memory decline, and it is recommended for cosmonauts for increasing physical and mental and cognitive activities in space. 5)Information letter from the Institute of Medical-Biological Problems of the Russian Academy of Sciences [in Russian; online]. Available from URL: http://www.pheno tropil.ru/img/articles/popup_01264.html [Accessed 2010 Jan 22]

Phenylpiracetam is reportedly beneficial to people who develop cognitive deficits and/or depression after encephalopathy and brain injuries. It increased quality of life in patients with encephalopathy after acute lesions (30 people), brain traumas (33 people) and gliomas surgery (36 people). The average minimental state examination (MMSE) scores (a standard 30-point questionnaire used to assess cognition) from baseline improved in all groups. In the end, anxiety improved and depression declined substantially, and that resulted in less discomfort and better ability to execute everyday activities. 6)Savchenko AIu, Zakharova NS, Stepanov IN. The phe- notropil treatment of the consequences of brain organic lesions [in Russian]. Zh Nevrol Psikhiatr Im S S Korsa- kova 2005; 105 (12): 22-6/ Kalinsky PP, Nazarov VV. Use of phenotropil in the treatment of asthenic syndrome and autonomic dis- turbances in the acute period of mild cranial brain trauma [in Russian]. Zh Nevrol Psikhiatr Im S S Korsakova 2007; 107 (2): 61-3

Phenylpiracetam was favored in the treatment of chronic vascular encephalopathy as it improved the cognitive performance in all tests, whereas only two of the eight test scores increased in the piracetam arm. 7)Gustov AA, Smirnov AA, Korshunova IuA, et al. Pheno- tropil in the treatment of vascular encephalopathy [in Russian]. Zh Nevrol Psikhiatr Im S S Korsakova 2006; 106 (3): 52-3

It also improved both asthenia and depression scores, albeit to a lesser extent in MS patients. 8)Sazonov DV, Ryabukhina OV, Bulatova EV, et al. Use of phenotropil in complex treatment of multiple sclerosis [in Russian]. Nervnye Bolezni 2006; 4: 18-21

In a comparative trial, asthenia and chronic fatigue syndrome (CFS) patients were treated with phenylpiracetam (68 people), piracetam (65 people) and placebo (47 people). The scores of the ten-word memory test and attention switching tests for the phenylpiracetam improved relative to those of piracetam and placebo. Overall, 83of asthenic and 87of CFS patients responded well to phenylpiracetam versus 48and 55%, respectively, to piracetam. 9)Akhapkina VI, Fedin AI, Avedisova AS, et al. Efficacy of Phenotropil for treatment of astenic and chronic fatigue syndromes [in Russian]. Nervnye Bolezni 2004; 3: 28-32

 In agreement with this, phenylpiracetam markedly increased the problem-solving skills of adolescents with asthenia who were A-players, B-players and C-players (i.e. the number of individuals able to respond to the memory and attention tests after the first, second and third attempts) from 11%, 15%, 73before to 23%, 40%, 37after treatment, respectively. It was superior to piracetam (400 mg/day) in combination with multivitamins and physiotherapy. 10)Zvonareva EV. Phenotropil in the therapy of cognitive disorders in teenagers with astenic syndrome [in Russian]. Nervnye Bolezni 2006; 2: 27-8

Human studies using Phenylpiractam:

phenylpiracetam-resources

Convulsion/Epilepsy, Seizure

Phenylpiracetam exhibited an antiepileptic action in rodents. Its effective dose (300 mg/kg) decreased the metrazol (a drug used as a circulatory and respiratory stimulant)-induced seizure by 50%. 11)Bobkov IuG, Morozov IS, Glozman OM, et al. Pharma- cological characteristics of a new phenyl analog of pir- acetam–4-phenylpiracetam [in Russian]. Biull Eksp Biol Med 1983 Apr; 95 (4): 50-3

Phenylpiracetam was administered to patients in addition to one standard AED (including valproyl amide, carbamazepine, lamotrigine, topiramate or a barbiturate, or structured polytherapy with more than one of these drugs). It substantially mitigated the number and frequency of seizures of patients receiving AED only and the number of individuals with a desynchronous EEG profile decreased from eight to three, while the number of individuals with seizure remissions increased modestly. 12)Bel’skaia GN, Ponomareva IV, Lukashevich IG, et al. Complex treatment of epilepsy with phenotropil [in Rus- sian]. Zh Nevrol Psikhiatr Im S S Korsakova 2007; 107 (8): 40-3

 Consistent with this, cognitive functions in epileptic patients based on an MMSE test improved to only a small extent. 13)Lybzikova GN, Iaglova ZhS, Kharlamova IuS. The effi- cacy of phenotropil in the complex treatment of epilepsy [in Russian]. Zh Nevrol Psikhiatr Im S S Korsakova 2008; 108 (2): 69-70.

Cerebral Stroke/Ischaemia

Because the immune system has a crucial role in the pathogenesis of ischaemia-stroke, titres of antibodies against the main myelin protein and phospholipids were measured in patients with acute cerebral stroke treated with phenylpiracetam. The titres of both antibodies decreased, suggesting possible reduction of ongoing demye-lination 14)Gerasimova MM, Chichanovskaia LV, Slezkina LA. The clinical and immunological aspects of the effects of phenotropil on consequences of stroke [in Russian]. Zh Nevrol Psikhiatr Im S S Korsakova 2005; 105 (5): 63-4 (table V). In a two-arm parallel trial with patients receiving one tablet (80 people) and two tablets (40 people) a day, both MMSE and severity of stroke scores improved significantly, while only showing a trend toward improvement in daily living activities (Barthel test). 15)Bagir LV, Batysheva TT, Boiko AN, et al. Use of pheno- tropil for early treatment of patients after stroke [in Russian]. Concilium Medicum 2006; 8 (8): 96-101

Vision/Glaucoma

The cause of blindness in glaucoma is optical neuropathy and ganglia cell apoptosis. Use of a neuroprotective agent in delaying or preventing ganglial cell death was the rationale of a recent trial. Phenylpiracetam was given to patients with unstable open-angle glaucomas after the eye pressures were normalized using ocular hypo- tensive therapy and laser trabeculoplasty. The average number of blind spots or islands of loss or impairment of visual acuity decreased, and glaucoma stabilized in 80of patients at 6-month follow-up 16)Basinskii SN, Basinskii AS. Neuroprotective effect of Fenotropil in unstabilized primary glaucoma [in Russian]. Russkii Med Zh 2007; 8 (4): 148-51 (table V). It is premature to conclude whether the trial favors phenylpiracetam because of the lack of a prospective placebo control and possible variables such as patient heterogeneity at the trial entry point.

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