The following information is provided by the manufacturer of PURENERGY and is being used below while our description is being reviewed by our legal team. Nootroo 2.0, which contains PURENERGY, officially launches August 1st and all orders going forward will receive the upgraded version at no additional cost.

PURENERGY is a novel, next-generation form of caffeine in a crystal with pterostilbene. This unique crystal structure and the addition of pterostilbene dramatically slows the absorption of the caffeine, extending the duration it is effective. After 3.5 hours, normal caffeine has little to no effect, while even at 6 hours, PURENERGY still exhibits significant effects on attention.

PURENERGYTM is an innovative patent-protected caffeine product that is a co-crystal of caffeine and pTeroPure® pterostilbene. PURENERGY provides a novel next-generation healthy and functional caffeine solution that can provide consumers with a sustained energy boost over a significantly extended period of time while offering formulators the ability to reduce the amount of caffeine needed to produce expected results. As demonstrated in a recently completed human clinical study, PURENERGY delivered almost 30% more caffeine into the blood over a longer period of time than caffeine taken by itself and it had a 25% extended half-life compared to caffeine alone. It also showed statistical significances at six hours for fatigue and concentration and a trend toward significances for energy, focus and concentration—caffeine did not.

PURENERGY was developed as a high-quality caffeine alternative by ChromaDex® Inc., which holds the exclusive worldwide patent rights for the ingredient. ChromaDex is working with several clients to incorporate PURENERGY into products with applications in energy, focus and concentration, weight management and sports nutrition. Specifically, PURENERGY provides the energy market with a solution to address growing regulatory scrutiny and consumer expectations. Regulatory agencies and consumer groups are closely examining the caffeine content in energy beverages and products, and ChromaDex’s PURENERGY offers companies producing these products a caffeine solution that will satisfy present and future expectations while delivering the same product performance results for the consumer.


PURENERGY is a patent-protected, next-generation caffeine alternative that is a combination of caffeine and pTeroPure pterostilbene; it is a co-crystallization of approximately 43% caffeine and 57% pTeroPure, the only clinicaly studied 99% pure nature-identical all-trans pterostilbene with seven patents issued or pending. In this formulation, pterostilbene and caffeine are held together by hydrogen bonding to form a co-crystal.

Comprising more than 50% of the formulation, pterostilbene is an important compound in PURENERGY. Pterostilbene is an analog of resveratrol found naturally in blueberries and grapes. Resveratrol is one of the compounds thought to contribute to the “French Paradox” associated with red wine consumption. Like resveratrol, it belongs to a class of compounds called stilbenoids, which are naturally produced by plants. The main difference between pterostilbene and resveratrol is structural, and the difference in structure causes pterostilbene to have a higher potential for cellular uptake (Lin 2009). Pterostilbene also has a much longer half-life in the blood than resveratrol, approximately 105 minutes versus 40 minutes (Remsberg 2008), and when administered orally, pterostilbene showed 80% bioavailability, higher than the 20% bioavailability of resveratrol (Kapetanovic 2011). In pTeroPure pterostilbene’s first prospective, randomized, double-blind, placebo-controlled human clinical trial finalized in 2012 and conducted at the University of Mississippi School of Medicine it was shown that pterostilbene helps maintain healthy blood pressure in subjects with blood pressure that is already within normal ranges.

PURENERGY is the first product available that bonds pterostilbene and caffeine as a co-crystal, and this co-crystallization enables numerous energy-related benefits over traditional caffeine.

What are the Benefits of PURENERGY?

As demonstrated through both human and animal studies, PURENERGY offers significant benefits in performance that
enable it to serve as a healthy and functional alternative to traditional caffeine. Specifically, PURENERGY offers more efficient delivery of caffeine into the blood; improved concentration, energy, alertness and focus levels compared to traditional caffeine; extended half-life compared to caffeine; and functional benefits stemming from pterostilbene. In 2013, the first human clinical study on PURENERGY was completed, and the results confirmed that PURENERGY offers statistically significant energy-related benefits over traditional caffeine. The purpose of the study was to determine the safety, relative bioavailability and pharmacokinetics of PURENERGY as compared to pTeroPure pterostilbene and caffeine alone. The study lasted approximately four weeks with subjects attending four test visits, receiving a different ingredient at each visit. At one test visit, subjects received pTeroPure, at one test visit caffeine, at one test visit PURENERGY and at one test visit a placebo. The study was single-blind cross-over study, so subjects did not know the ingredient identity. There were no adverse events observed in the study.