BeePC 157 is BPC 157 Stable Version for Bee Research

BPC 157 found within a protein in the gastric juices of humans that helps the body activate its innate healing processes. BPC 157 is a 15 chain amino acid fragment that is derived from the larger BPC protein that is found in humans. Researchers found that "this fragment retained practically all effects of the natural BPC protein" and was "most responsible for the biological activity of the entire protein."

BPC 157 helps the honeybee repair its midgut wall layers and epithelial cells

BPC 157 is a peptide sequence found within a protein in the gastric juices of humans that helps the body activate its innate healing processes. BPC 157 is a 15 chain amino acid fragment that is derived from the larger BPC protein that is found in humans. Researchers found that “this fragment retained practically all effects of the natural BPC protein” and was “most responsible for the biological activity of the entire protein.”

All of the BPC 157 you see sold elsewhere is either in the free form or acetate form. The problem with these forms of BPC and many other peptides is that they are not stable at high temperatures such as those found in the body and are especially unstable in the high pH environment of the stomach. They can also be destroyed by UV light.

To counter these shortcomings the original developer and patent holders of BPC 157 made a form known as BPC 157 Stable Version which is BPC reacted with the amino acid L-arginine to form a salt. This salt form, BPC 157 Stable Version, is stable for longer at higher temperatures and in higher pH levels. It is also stable in UV light.

BPC 157 Stable Patented by Diagen

The patent for BPC 157 was approved in 2017 and Nootroo is now the exclusive USA and Canada distributor of BPC 157 Stable, directly from the inventors or BPC and patent holder, Diagen.

We will share some excerpts from the patent below, including proof of stability in various environments and the demonstrated superiority of the salt form vs the traditional acetate.

BPC 157 Stable Version - Stability In Light

Compounds of such type are very susceptible to ultraviolet light. An aqueous solution of Arg-BPC (1 g/100 ml of water) at 20° C. was radiated with ultraviolet light of a wavelength of 253.7 nm and absorption was measured within wavelength range from 230 to 350 nm over a period of 70 min every 10 min. The results are represented in FIG. 1 and confirm that the compound is stable.

BPC 157 Content Decrement in Acidic Environment

The fundamental problem to be solved is stability of the compound at an increased temperature, in particular the stability in gastric juice. The present invention relates to novel pentadecapeptide salts with basic amino acids having significantly improved thermal stability and also stability in gastric juice.

Gastric juice is a complex mixture of different compounds and the main components are: water, sodium chloride, hydrochloric acid, mucins, enzymes, particularly pepsin, and others. Gastric juice is mainly acidic; its pH value varies from 1 to 7 and exceptionally higher. Normal pH values are in the range from 2 to 5, which is also the range of the greatest activity of pepsin which decomposes polypeptides, peptides and proteins.

Stability of a compound in gastric juice is an important parameter, particularly in peptides, which very rapidly decompose in the presence of pepsine enzyme and in an acidic medium. Better stability in gastric juice means a longer period, in which the compound is available for resorption and its therapeutical activity.

The results of stability determination show that bepecin salts with basic amino acids are substantially more stable than other hitherto known salts of pentadecapeptide in question, which is surprisingly a huge advantage.

A consequence of better stability is also better biological activity, since the intact compound is present in an organism for a longer period of time and available for more efficient resorption.

BPC 157 Stable Patented by Diagen

The patent for BPC 157 was approved in 2017 and Nootroo is now the exclusive USA and Canada distributor of BPC 157 Stable, directly from the inventors or BPC and patent holder, Diagen.

We will share some excerpts from the patent below, including proof of stability in various environments and the demonstrated superiority of the salt form vs the traditional acetate.