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BPC 157 Stable Version

Body Protective Compound is a protein sequence found in the stomach of humans that is released by the body’s gastric juices to help the body activate its innate healing processes against stress. BPC 157 is a 15 chain amino acid fragment of that protein. Researchers found that “this fragment retained practically all effects of the natural BPC protein” and was “most responsible for the biological activity of the entire protein.”

Nearly all of the BPC 157 sold online, except unless specifically stated as otherwise, is the acetate form. Nootroo has acquired the patented BPC 157 Stable Form (ARG-BPC, BPC 2x – L Arginine Salt) directly from the patent holder, Diagen.  The problem with BPC 157 Acetate (and with many other peptides) is that they are not stable in the temperature of the human body and are especially unstable in the high pH environment of the stomach, meaning that the peptide is quickly destroyed. They can also be destroyed by UV light.

To counter these shortcomings the original developer and patent holders of BPC 157 made an improved version known as BPC 157 Stable Version which is BPC reacted with the amino acid L-arginine to form a salt. This salt form, BPC 157 Stable Version, is stable for longer at higher temperatures and in higher pH levels. It is also stable in UV light, as the data below from the patent demonstrates.

BPC 157 Stable Patented by Diagen

The patent for BPC 157 was approved in 2017 and Nootroo is now and is selling it under the BeePC 157 brand in the only US, Candian, and Mexican.

You can read the full patent to the right, from which we will share some excerpts from the patent below, including proof of stability in various environments and the demonstrated superiority of the salt form vs the traditional acetate in gastric juices.

BPC 157 Stable Version Patent: Stable pentadecapeptide salts, a process for preparation thereof, a use thereof in the manufacture of pharmaceutical preparations and a use thereof in therapy

BPC 157 Stable Patent Diagen

BPC 157 Stable Version - Stability In Light

Compounds of such type are very susceptible to ultraviolet light. An aqueous solution of Arg-BPC (1 g/100 ml of water) at 20° C. was radiated with ultraviolet light of a wavelength of 253.7 nm and absorption was measured within wavelength range from 230 to 350 nm over a period of 70 min every 10 min. The results are represented in FIG. 1 and confirm that the compound is stable.

BPC 157 Stable's Demonstrated Stability in Stomach Like Acidity

"The fundamental problem to be solved is stability of the compound at an increased temperature, in particular the stability in gastric juice. The present invention relates to novel pentadecapeptide salts with basic amino acids having significantly improved thermal stability and also stability in gastric juice.

Gastric juice is a complex mixture of different compounds and the main components are: water, sodium chloride, hydrochloric acid, mucins, enzymes, particularly pepsin, and others. Gastric juice is mainly acidic; its pH value varies from 1 to 7 and exceptionally higher. Normal pH values are in the range from 2 to 5, which is also the range of the greatest activity of pepsin which decomposes polypeptides, peptides and proteins.

Stability of a compound in gastric juice is an important parameter, particularly in peptides, which very rapidly decompose in the presence of pepsine enzyme and in an acidic medium. Better stability in gastric juice means a longer period, in which the compound is available for resorption and its therapeutical activity.

The results of stability determination show that bepecin salts with basic amino acids are substantially more stable than other hitherto known salts of pentadecapeptide in question, which is surprisingly a huge advantage.

A consequence of better stability is also better biological activity, since the intact compound is present in an organism for a longer period of time and available for more efficient resorption."

Source: BPC 157 Stable Salts Patent - Section "Detailed Description of the Invention"

A visual example of BPC 157's effect on wound healing:

Selected BPC 157 Reseach:

The research on the non-stable BPC 157 acetate applies to BPC 157 Stable Form. However, since BPC 157 Stable is significantly more stable in the gastric juices and higher temperatures of animals, research "dose" sizes can be adjusted downward.

BPC 157’s Effect on Healing

BPC 157’s Effect on Healing

Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing

Gastric pentadecapeptide boyd protection compound bpc 157 and its role in accelerating musculoskeletal soft tissue healing

Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth

Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth

Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing

Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing

Pentadecapeptide BPC 157 (PL 14736) Improves Ligament Healing in the rat

Pentadecapeptide BPC 157 (PL 14736) Improves Ligament Healing in the rat

Brain-gut Axis and Pentadecapeptide BPC 157 Theoretical and Practical implications

Brain-gut Axis and Pentadecapeptide BPC 157 Theoretical and Practical implications

A new gastric juice peptide BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC

A new gastric juice peptide BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC

The pharmacological properties of the novel peptide BPC 157

The pharmacological properties of the novel peptide bpc 157

BPC 157 Stable To Save The Bees

As normal BPC 157 Acetate is not stable below room temperature or fully orally available, it is unsuitable for experiments where it will be left outside in the light or out of a refridgerator for a while. Fortunately, BPC 157 Stable overcomes these weaknesses and as such this new form has been tested to help save bees from the deadly fungal parasite Nosema ceranae.

The parasite Nosema ceranae contributes to colony collapse of bees because once infected, the parasite grows in the stomach, interfere with osmotic pressure and causes a deterioration of the Bee's midgut lining and epithelial cells. Fortunately, BPC 157 as a gastric peptide, can cause the healing of that lining, preventing the bee death and thwarting the collapse of colonies.

Stable gastric pentadecapeptide BPC 157 in honeybee (Apis mellifera) therapy, to control Nosema ceranae invasions in apiary conditions

Stable gastric pentadecapeptide BPC 157 in honeybee (Apis mellifera) therapy, to control Nosema ceranae invasions in apiary conditions

Introducing BeePC 157 Stable Version

BPC 157 Stable To Save The Bees

As normal BPC 157 Acetate is not stable below room temperature or fully orally available, it is unsuitable for experiments where it will be left outside in the light or out of a refridgerator for a while. Fortunately, BPC 157 Stable overcomes these weaknesses and as such this new form has been tested to help save bees from the deadly fungal parasite Nosema ceranae.

The parasite Nosema ceranae contributes to colony collapse of bees because once infected, the parasite grows in the stomach, interfere with osmotic pressure and causes a deterioration of the Bee's midgut lining and epithelial cells. Fortunately, BPC 157 as a gastric peptide, can cause the healing of that lining, preventing the bee death and thwarting the collapse of colonies.

While we cite various studies demonstrating the current research data on BPC 157, but this is not an endorsement or suggestion for use. BPC 157 Stable, sold here as BeePC 157, is sold for use only in apiary research only and is not for human consumption. BPC 157 Stable / BeePC 157 is not intended to diagnose, treat, cure, or prevent any disease. Purchasers must be adults aged 18 and older. BPC 157 Stable / BeePC 157 is not a vitamin, mineral, amino acid, herb or other botanical, or dietary substance for use by man to supplement the diet by increasing the total dietary intake. While BPC 157 is highly pure, with the latest batch being 99.8% purity and it is filtered by fine filtration through a filter with 0.22 μm pores, this product is not legally considered “sterile.”