Nootroo 5.0 Has Arrived

Upgraded Formula, Upgraded Brain.

 

Nootroo 5.0

Upgraded Formula, Upgraded Brain.

Humanity will not wait millions of years until Mother Nature will hand it a functionally better brain...[Humankind] will directly, openly and consciously take part in evolution.

Corneliu Giurgea (1923-1995)Father of the Nootropic Concept

Nootropics: Towards the Mind

Nootropics are a category of molecules that work selectively "towards the mind." Nootropics act directly on the higher-level, integrative activity of the brain that ultimately controls and integrates the processes related to learning, memory formation, consolidation, recall and overall cognitive efficacy. Their selective action must occur while also being non-toxic, and virtually free of side-effects.

If that description sounds unlike anything else you have heard of, you can imagine how flummoxed the researchers who discovered the original nootropic molecule were. In 1964, while modifying a neurotransmitter in pursuit of a sleep aid, they discovered something much more profound, a molecule with properties so unique (see below), that in order to classify it, the formation of an entirely new class was required: Nootropics.

Enhance Learning & Memory

Improves learning acquistion and enhances resistance to learning impairment from casues such as lack of oxygen (hypoxia), electroconvulsive shock (ECS), and chemicals that tend to prevent memory formation.

Facilitate of Interhemispheric Transfer & Synchronization

Facilitates the transfer of information from one hemisphere to the other across the corpus callosum and increases synchronization between the hemispheres.

Non-Stimulant & Non-Sedative

Works by increasing integration of higher-level (telencephalic) activity. On over 30 classical pharmacological tests, the original nootropic shows no activity, including as neither a central nervous stimulant nor a sedative.

Strengthen Control of Subcortical Processes

While not acting on directly the CNS, nootropics are still able to modulate cortical tonic control, as seen in central nystagmus and spinal fixiation.

Enhance Cerebral Resistance

Increases the brain's ability to resist aggressions and increases recovery time after loss of oxygen, physical trauma, and many chemical intoxications.

Non-Toxic & Low-to-No Side Effects

Must work in harmony with the brain, being virtually free of side-effects and non-toxic even in high doses. It must not be habit-forming or cause withdrawal.

About Nootroo

Nootroo is a nootropics company founded in 2014 by Eric Matzner and is based in San Francisco's Misson District. Nootroo's tagline is "The Gold Standard In Nootropics™" because of our dedication to creating the best nootropics possible, by using only the purest, most-effective ingredients and never cutting any corners. Our products use no additives, fillers, binding agents or artificial colors, just pure, lab-tested nootropics.

Our Gold and Silver 5.0 Formulas have been developed over 5 iterations and combine the over 50 years of research on nootropics, with cutting-edge advances in neuroscience, and insights from the worlds leading biohackers, to create the best nootropics stacks ever produced.

The Magic Behind Nootroo:

Next-Generation Nootropics

Synergistic Formulations

Protocol For Optimal Performance

As Featured In:

BBC’s Health Episode of “Billion dollar Deals and How They Changed Your World” 3:44

The BBC came to check out what is going on in Silicon Valley with those choosing to enhance their biology and push forward science, to see if they just might end up pushing forward the world.

ABC Nightline News Feature On Nootropics 2:27

Nightline News dropped by to see what all the hype over nootropics is about. They interviewed a Nootroo customer to find “the secret to her work hard play hard lifestyle.”

How to Live Forever: The Morning Routine of a Biohacker 1:38

NPR wanted some tips on how biohacker and Nootroo founder, Eric Matzner, starts his day, so he showed them the Nootroo Protocol.

History & Discovery of Nootropics

To understand the nootropic concept, it necessary to understand how the search for a sleep aid, led to the formation of a class of agents that act directly "towards the mind."

History

Nootroo 5.0 & Ingredients

Nootroo Gold & Silver 5.0 stacks are based on the "profound effects" that come from combining nootropic agents and a choline source. Click through to learn how we have fully optimzed our stacks.

Nootroo 5.0

Protocol & Research

Dive into full-text studies on the nootropic concept, ingredients in Nootroo and how to bring it all together with the Nootroo Protocol

Research

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History of Nootropics

In 1964, scientists at UCB Pharma in Belgium were attempting to make a version of the inhibitory neurotransmitter GABA, that would be able to cross the blood-brain barrier. Which they hypothesized might act as a sleep-aid. Instead they accidentally discovered a molecule with properties so profound and unique that in order to classify it, the creation of an entirely new class  of compounds was required: Nootropics.

That molecule, which would later be known as Piracetam, was able to prevent the disruption of memory formation in rats when they experienced a loss of oxygen (hypoxia) or were electroconvulsively shocked (ECS). It was also shown to bring back higher-level brain function to oxygen-deprived rats, nearly double as quickly as the control. 1)Giurgea, C., Mouravieff-Lesuisse, F., and Leemans, R.: Correlations electropharmacologiques au cours de l’anoxie oxyprive chez le lapin en respiration libre ou artificielle. Rev. Neurol. (Paris), 122:484-486, 1970.

What piqued their attention was not only that it was able to do all of that and more, but that it did so while being extremely safe and while showing no activity on over 30 psychopharmacological tests, including behavioral tests demonstrating that it was neither a stimulant nor a sedative. 2)Giurgea, C., Moyersoons, F., and Evraerd, A. C.: A GABA related hypothesis on the mechanism of action of the antimotion sickness drugs. Arch. Int. Pharmacodyn. Ther. 166:238-251, 1967.

Piracetam appeared to act directly on higher brain, integrative activity, increasing efficacy, and decreasing deficits. After studying these properties for 9 years, in 1972 Corneliu Giurgea coined the term nootropics, meaning “towards the mind.” 3)The “Nootropic” Approach to the Pharmacology of the Integrative Activity of the Brain C. GIUIRGEA, M.D. 1972

The original nootropic was found to enhance learning in healthy humans.

The Prototype Nootropic

The prototype nootropic, piracetam, soon began to see use in a range of populations, from pre-dementia elderly patients to young kids with ADHD. In 1976 it was tested in healthy college students and was found to increase their verbal learning.

The Nootropic Revolution

Learning that nootropics could be used to enhance the brains of healthy individuals set off a revolution in science and lead to the creation of additional nootropic molecules that were more targeted and powerful than piracetam.

Profound effects combining nootropics and choline source

Synergy

Nootroo's formulas are based on the "profound effects" found when combining a nootropic agent along with a choline source. In our Gold Formula we use the nootropic agent Noopept and in our Silver Formula we use the nootropic Phenylpiracetam. Both formulas are then combined with the bioidentical form of choline typically found in foods, called Citicoline or CDP-Choline. The synergistic effect of combining these agents is greater than either agent alone, as can be seen in the Gold Bar in the accompanying image. The bar highlighted Gold and labeled as "C + P" (Citicoline + Piracetam), is from an experiment model on aged rates that demonstrates memory retention after 24 hours.

Boosting neurotransmitters

One mechanism of action of nootropics is to increase the ability of the brain to increase its usage of the neurotransmitter acetylcholine, which regulates memory formation and synapse firing 4)Bartus, R. T., R. L. Dean, J. A. Goas and A. S. Lippa. Age-
related changes in passive avoidance retention: Modulation with
dietary choline. Science 209: 301-303, 1980.
. By supplementing the building blocks of acetylcholine, the brain will then create more of that neurotransmitter in the brain, which the main nootropics then bring into the hippocampus (where memory is formed).

Development of more powerful nootropic agents

Targeted Enhancement

As mentioned, piracetam was discovered accidentally, so as scientists began to learn the beneficial properties of the molecule and the methods of action, they set out to design more powerful and targeted versions. They typically kept the core structure of the proline molecule and made other modifications. You can see in the accompanying image, some of the variations that have been discovered. Of those, Phenylpiracetam and Noopept stood out with dramatically more powerful nootropic effects and were fully developed all the way through successful clinical trials in humans.

Advanced Versions

Phenylpiracetam was designed to retain the cognitive enhancing aspects of piracetam, while also working to enhance endurance and processing speed. Noopept was designed as a peptide version of piracetam that would be significantly more powerful and orally bioavailable, and by chance had calming ("anxiolytic") properties. These are the nootropics selected for use in our formula due to the wide body of research on both, including decades of clinical use with demonstrated and well-known pharmacokinetics, as well as the general perception within the nootropics community that they are the best. Our Gold Formula contains Noopept and our Silver Formula contains Phenylpiracetam..

Formulas & Ingredients

We have combined over 50 years of research on nootropics with cutting-edge neuroscience and insights from the worlds leading biohackers to develop the Nootroo Gold & Silver Formulas.

A 30-count bottle of Nootroo Gold & Silver contains 15 capsules of the Gold Formula and 15 capsules of the Silver Formula.

The Gold formula contains Noopept and Citicoline and the Silver Formula contains Phenylpiracetam and Citicoline.

The Formulas are designed to be alternated between daily.

Noopept

Noopept was developed to be a more bioavailable version of the original nootropic piracetam based on a neuropeptide. Researchers succeeded beyond their expectations and created a molecule significantly more potent by molecular weight, which also has more pronounced neuroprotective and memory restoring properties.5)Ostrovskaya RU, Romanova GA, Barskov IV, Shanina EV, Gudasheva TA, Victorov IV, Voronina TA, Seredenin SB (1999). “Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model”. Behavioural Pharmacology 10 (5): 549–553. In studies on the Alzheimer’s disease model, Noopept has restored spatial memory and increased immunoreactivity to amyloid buildup. 6)Ostrovskaya RU, Gruden MA, Bobkova NA, Sewell RD, Gudasheva TA, Samokhin AN, Seredinin SB, Noppe W, Sherstnev VV, Morozova-Roche LA (2007). “The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model”. Journal of Psychopharmacology 21 (6): 611–619. Studies also show Noopept to stimulate the expression of Nerve Growth Factor (NGF) and Brain-Derived Neurotropic Factor (BDNF) in the hippocampus and cerebral cortex. BDNF is a protein that is crucial in determining the quantity of new neurons the brain can create, as well as regulating growth, survival and, differentiation of existing neurons.7)” We showed that the nootropic drug increases expression of neurotrophic factors in the hippocampus. Our results are consistent with the hypothesis that neurotrophin synthesis in the hippocampus determines cognitive function, particularly in consolidation and delayed memory retrieval. Published data show that neurotrophic factor deficiency in the hippocampus is observed not only in advanced Alzheimer’s disease, but also at the stage of mild cognitive impairment (predisease state). In light of this, our findings suggest that Noopept holds much promise to prevent the development of Alzheimer’s disease in patients with mild cognitive impairment. Moreover, therapeutic effectiveness of Noopept should be evaluated at the initial stage of Alzheimer’s disease.”

Learn More

Phenylpiracetam

Phenylpiracetam is a nootropic substance that was developed in Russia in 1983 and is chemically related to Piracetam, but considered 30-60 times stronger. A single dose of phenylpiracetam has been shown to cause a “significant increase in locomotor activity” and a “significantly enhanced memory function” in a passive avoidance test.8)Zvejniece L, <em>et al</em>. <a href=”http://www.ncbi.nlm.nih.gov/pubmed/21689376″ target=”_new” rel=”nofollow”>Investigation into stereoselective pharmacological activity of phenotropil</a>. <em>Basic Clin Pharmacol Toxicol</em>. 2011. It has also been shown to “increase physical endurance” and “resistance to cold”9) “Carphedon is a phenyl derivative of nootropil and is effective in increasing physical endurance and cold resistance, and is used for amnesia treatment.” Analyst. 1999 Nov;124(11):1559-62. <a href=”http://www.ncbi.nlm.nih.gov/pubmed/10746314″>PMID: 10746314</a>.  It has been shown to increase cognitition in persons with cognitive decline from organic causes.10)Lybzikova GN, Iaglova ZhS, Kharlamova IuS. The efficacy of phenotropil in the complex treatment of epilepsyZh Nevrol Psikhiatr Im S S Korsakova. (2008) It has also been shown to improve cognition in youth with epilepsy. In rodent trials Phenylpiracetam has been shown to improve retention latency by over 185%. 11)Zvejniece L, et alInvestigation into stereoselective pharmacological activity of phenotropilBasic Clin Pharmacol Toxicol.

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In Both Formulas:

Citicoline

Citicoline is a precursor for the memory neurotransmitter acetylcholine, and supplementation has been shown to increase acetylcholine production in the brain. Citicoline administration has also been shown to increase brain bioenergetics by increasing energy reserves and utilization of energy. It’s administration also increases the amount of essential phospholipid membrane components needed to synthesize and maintain cell membranes12)Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy.. Studies in healthy women show that taking Cognizin citicoline significantly improved their verbal memory after just 28 days13)Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women Studies suggest that citicoline also can help increase dopamine receptor densities 14)Giménez R, Raïch J, Aguilar J (November 1991).”Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-Choline treatment of aging mice”. British Journal of Pharmacology 104(3): 575–8., which is the neurotransmitter associated with motivation. Cognizin is a patented form of Citicoline that is created in a bioreactor process that takes 6 months and yields the only pure, free-base form of citicoline that is bioidentical to the form found in nature.

Learn More

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References   [ + ]

1. Giurgea, C., Mouravieff-Lesuisse, F., and Leemans, R.: Correlations electropharmacologiques au cours de l’anoxie oxyprive chez le lapin en respiration libre ou artificielle. Rev. Neurol. (Paris), 122:484-486, 1970.
2. Giurgea, C., Moyersoons, F., and Evraerd, A. C.: A GABA related hypothesis on the mechanism of action of the antimotion sickness drugs. Arch. Int. Pharmacodyn. Ther. 166:238-251, 1967.
3. The “Nootropic” Approach to the Pharmacology of the Integrative Activity of the Brain C. GIUIRGEA, M.D. 1972
4. Bartus, R. T., R. L. Dean, J. A. Goas and A. S. Lippa. Age-
related changes in passive avoidance retention: Modulation with
dietary choline. Science 209: 301-303, 1980.
5. Ostrovskaya RU, Romanova GA, Barskov IV, Shanina EV, Gudasheva TA, Victorov IV, Voronina TA, Seredenin SB (1999). “Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model”. Behavioural Pharmacology 10 (5): 549–553
6. Ostrovskaya RU, Gruden MA, Bobkova NA, Sewell RD, Gudasheva TA, Samokhin AN, Seredinin SB, Noppe W, Sherstnev VV, Morozova-Roche LA (2007). “The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model”. Journal of Psychopharmacology 21 (6): 611–619.
7. ” We showed that the nootropic drug increases expression of neurotrophic factors in the hippocampus. Our results are consistent with the hypothesis that neurotrophin synthesis in the hippocampus determines cognitive function, particularly in consolidation and delayed memory retrieval. Published data show that neurotrophic factor deficiency in the hippocampus is observed not only in advanced Alzheimer’s disease, but also at the stage of mild cognitive impairment (predisease state). In light of this, our findings suggest that Noopept holds much promise to prevent the development of Alzheimer’s disease in patients with mild cognitive impairment. Moreover, therapeutic effectiveness of Noopept should be evaluated at the initial stage of Alzheimer’s disease.”
8. Zvejniece L, <em>et al</em>. <a href=”http://www.ncbi.nlm.nih.gov/pubmed/21689376″ target=”_new” rel=”nofollow”>Investigation into stereoselective pharmacological activity of phenotropil</a>. <em>Basic Clin Pharmacol Toxicol</em>. 2011
9.  “Carphedon is a phenyl derivative of nootropil and is effective in increasing physical endurance and cold resistance, and is used for amnesia treatment.” Analyst. 1999 Nov;124(11):1559-62. <a href=”http://www.ncbi.nlm.nih.gov/pubmed/10746314″>PMID: 10746314</a>
10. Lybzikova GN, Iaglova ZhS, Kharlamova IuS. The efficacy of phenotropil in the complex treatment of epilepsyZh Nevrol Psikhiatr Im S S Korsakova. (2008)
11. Zvejniece L, et alInvestigation into stereoselective pharmacological activity of phenotropilBasic Clin Pharmacol Toxicol.
12. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy.
13. Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women
14. Giménez R, Raïch J, Aguilar J (November 1991).”Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-Choline treatment of aging mice”. British Journal of Pharmacology 104(3): 575–8.