"Man will not wait passively for millions of years for evolution to offer him a better brain"

Corneliu Giurgea

Father of the Nootropic Concept

Nootropics are substances that enhance learning and memory while protecting the brain. The term nootropics means “towards the mind” and is defined a class of substances specifically targeting higher-level, integrative activity of the brain.

To be defined as a nootropic a substance must meet all of the following characteristics:

  • Enhance learning and memory
  • Protect the brain from physical or chemical injury
  • Enhance the firing mechanisms of neurons
  • Have few side effects and extremely low toxicity
  • Prevent the disruption of memory formation from conditions which tend to disrupt them.
Highest Possible Quality

Nootroo is The Gold Standard In Nootropics™ because we use the purest ingredients in the industry, as backed up by 3rd-party lab testing.

No Gimmicks, Fillers, or Additives

Our products use no additives, fillers, binding agents, artificial colors or other BS. Just pure, unadulterated nootropics.

Most Powerful Formulas

Our formulas are the most powerful single-capsule nootropic blends ever created.

Synergistic Ingredients

Engineered with ingredients that work together in synergistic ways to become more powerful than any of the individual ingredients on their own.

History of Nootropics

In the early 1960s, scientists at a lab in Belgium modified the neurotransmitter GABA in the pursuit of creating a sleep-aid, but instead they discovered a molecule with properties so unique that in order to classify it, the creation of an entirely new class  of compounds was required.

The term “nootropics” is derived from the greek words “noos” and “tropein” meaning “towards the mind.” The nootropic concept was introduced in 1972 by neuropharmacologist Corneliu Giurgea. Nootropics are defined as molecules that act specifically towards higher-level, integrative activity in the brain.

The original nootropic was found to enhance learning in healthy humans.

The Prototype Nootropic

The prototype nootropic, piracetam, soon began to see use in a range of populations, from pre-dementia elderly patients to young kids with ADHD. In 1976 it was tested in healthy college students and was found to increase their verbal learning.

The Nootropic Revolution

Learning that nootropics could be used to enhance the brains of healthy individuals set off a revolution in science and lead to the creation of additional nootropic molecules that were more targeted and powerful than piracetam.

Development of more powerful nootropic agents

Targeted Enhancement

As mentioned, piracetam was discovered accidentally, so as scientists began to learn the beneficial properties of the molecule and the methods of action, they set out to design more powerful and targeted versions.

Advanced Versions

Two of the most promising versions of piracetam discovered over the ensuing decades of research were phenylpiracetam and noopept. Phenylpiracetam retained the cognitive enhancement aspects of piracetam, while enhancing psychomotorstimulation. Noopept was designed as a peptide version of piracetam that would target nootropic effects deeper in the brain and has additonal calming properties.

Profound effects combining nootropics and choline source

Boosting neurotransmitters

One mechanism of action of nootropics is to increase the usage of the neurotransmitter acetylcholine. By supplementing the building blocks of acetylcholine, the brain will then create more of that neurotransmitter in the brain.

Synergy

When combining nootropics like piracetam with a source of choline, there is a synergistic effect that is profoundly better than either alone.

Ingredients and Instructions

Nootroo comes in two different formulas, a Gold formula and a Silver formula. The Gold formula contains Noopept Cognizin brand citicoline and in the Silver is Phenylpiracetam and Cognizin brand citicoline.

The pills are alternated between daily, one day Gold, and the next day Silver.

Noopept

Noopept has been shown in animal studies to be neuroprotective and to help to enhance and restore memory1)Ostrovskaya RU, Romanova GA, Barskov IV, Shanina EV, Gudasheva TA, Victorov IV, Voronina TA, Seredenin SB (1999). “Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model”. Behavioural Pharmacology 10 (5): 549–553.doi:10.1097/00008877-199909000-00013.PMID 10780261. In studies with the Alzheimer’s disease model, Noopept has restored spatial memory and increased immunoreactivity to amyloid buildup. 2)Ostrovskaya RU, Gruden MA, Bobkova NA, Sewell RD, Gudasheva TA, Samokhin AN, Seredinin SB, Noppe W, Sherstnev VV, Morozova-Roche LA (2007). “The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model”. Journal of Psychopharmacology 21 (6): 611–619.doi:10.1177/0269881106071335.  17092975.

Studies also show Noopept to stimulate the expression of Nerve Growth Factor (NGF) and Brain-Derived Neurotropic Factor (BDNF) in the hippocampus and cerebral cortex. The hippocampus is the region of the brain responsible for the formation of memories and consolidation of short-term memory to long-term memory. BDNF is a protein that is crucial in determining the quantity of new neurons the brain can create, as well as regulating growth, survival and, differentiation of existing neurons.3)” We showed that the nootropic drug increases expression of neurotrophic factors in the hippocampus. Our results are consistent with the hypothesis that neurotrophin synthesis in the hippocampus determines cognitive function, particularly in consolidation and delayed memory retrieval. Published data show that neurotrophic factor deficiency in the hippocampus is observed not only in advanced Alzheimer’s disease, but also at the stage of mild cognitive impairment (predisease state). In light of this our findings suggest that Noopept holds much promise to prevent the development of Alzheimer’s disease in patients with mild cognitive impairment. Moreover, therapeutic effectiveness of Noopept should be evaluated at the initial stage of Alzheimer’s disease.” http://link.springer.com/article/10.1007%2Fs10517-008-0297-x

Phenylpiracetam

Phenylpiracetam is a nootropic substance that has been shown to improve cognition in persons with cognitive decline from organic causes.4)Lybzikova GN, Iaglova ZhS, Kharlamova IuS. The efficacy of phenotropil in the complex treatment of epilepsyZh Nevrol Psikhiatr Im S S Korsakova. (2008) It has also been shown to improve cognition in youth with epilepsy. In rodent trials Phenylpiracetam has been shown to improve retention latency by over 185%. 5)Zvejniece L, et alInvestigation into stereoselective pharmacological activity of phenotropilBasic Clin Pharmacol Toxicol.

A single dose of phenylpiracetam has been shown to cause a “significant increase in locomotor activity” and a ‘significantly enhanced memory function in a passive avoidance response test” in rodents. 6)Zvejniece L, et alInvestigation into stereoselective pharmacological activity of phenotropilBasic Clin Pharmacol Toxicol. (2011)

Phenylpiracetam has also been shown to be effective in increasing physical endurance, adaptation and resistance to cold. 7) “Carphedon is a phenyl derivative of nootropil and is effective in increasing physical endurance and cold resistance, and is used for amnesia treatment.” Analyst. 1999 Nov;124(11):1559-62. PMID: 10746314.

cognizin logo black

Citicoline

Citicoline is a precursor for the memory neurotransmitter and supplementation has been shown to increase acetylcholine production in the brain. Studies in healthy women show that taking Cognizin citicoline their verbal memory after just 28 days. Studies suggest that citicoline also can help increase dopamine receptor densities 8)Giménez R, Raïch J, Aguilar J (November 1991).“Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice”British Journal of Pharmacology 104(3): 575–8. doi:10.1111/j.1476-5381.1991.tb12471.x.PMC 1908237PMID 1839138., which is the neurotransmitter associated with motivation. Citicoline has been shown to help improve focus and mental energy 9)“Supplement naturally boosts ageing brain power”Sydney Morning Herald. 2008-02-25. Retrieved 2009-07-28., as well as helping with the treatment of attention deficit disorder. 10)Silveri MM, Dikan J, Ross AJ, et al. (November 2008). “Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy”. NMR in Biomedicine 21 (10): 1066–75.doi:10.1002/nbm.1281PMID 18816480

Nootropics are marketed as pills that will increase your productivity and boost your brain power...in Silicon Valley, nootropics have become part of a subculture that is trying to work as many productive hours a day as possible.

For the productivity-obsessed of Silicon Valley, coffee alone may not cut it anymoreNPR's Marketplace

For many users, nootropics are not just a productivity tool; they’re part of a holistic journey toward perfection of the mind, body, and soul.

The Brain BroAtlantic Magazine

If you peer through the hype around nootropics, there is something interesting afoot.

Nootropics and the Human Lab Rats of RedditGizmodo

People are going to upgrade themselves with technology. This is the beginning, the technology of the mind that will do what would have taken [evolution] millions of years

'Nootropics’ gain momentum as 'smart pills’San Francisco Chronicle

Nootroo Press Videos

Get some perspectives on Nootroo and our Founder Eric Matzner

Nootroo on ABC’s Nightline News 2:27

ABC Nightline news clip featuring Nootroo and Nootropics

How to Live Forever: The Morning Routine of a Biohacker 1:38

Check out the morning routine of Nootroo Founder, Eric Matzner.  He demonstrates an express version of the Nootroo Protocol to prove that most aspects can be achieved within 10 minutes of being awake.

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References   [ + ]

1. Ostrovskaya RU, Romanova GA, Barskov IV, Shanina EV, Gudasheva TA, Victorov IV, Voronina TA, Seredenin SB (1999). “Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model”. Behavioural Pharmacology 10 (5): 549–553.doi:10.1097/00008877-199909000-00013.PMID 10780261
2. Ostrovskaya RU, Gruden MA, Bobkova NA, Sewell RD, Gudasheva TA, Samokhin AN, Seredinin SB, Noppe W, Sherstnev VV, Morozova-Roche LA (2007). “The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model”. Journal of Psychopharmacology 21 (6): 611–619.doi:10.1177/0269881106071335.  17092975.
3. ” We showed that the nootropic drug increases expression of neurotrophic factors in the hippocampus. Our results are consistent with the hypothesis that neurotrophin synthesis in the hippocampus determines cognitive function, particularly in consolidation and delayed memory retrieval. Published data show that neurotrophic factor deficiency in the hippocampus is observed not only in advanced Alzheimer’s disease, but also at the stage of mild cognitive impairment (predisease state). In light of this our findings suggest that Noopept holds much promise to prevent the development of Alzheimer’s disease in patients with mild cognitive impairment. Moreover, therapeutic effectiveness of Noopept should be evaluated at the initial stage of Alzheimer’s disease.” http://link.springer.com/article/10.1007%2Fs10517-008-0297-x
4. Lybzikova GN, Iaglova ZhS, Kharlamova IuS. The efficacy of phenotropil in the complex treatment of epilepsyZh Nevrol Psikhiatr Im S S Korsakova. (2008)
5. Zvejniece L, et alInvestigation into stereoselective pharmacological activity of phenotropilBasic Clin Pharmacol Toxicol.
6. Zvejniece L, et alInvestigation into stereoselective pharmacological activity of phenotropilBasic Clin Pharmacol Toxicol. (2011)
7. “Carphedon is a phenyl derivative of nootropil and is effective in increasing physical endurance and cold resistance, and is used for amnesia treatment.” Analyst. 1999 Nov;124(11):1559-62. PMID: 10746314
8. Giménez R, Raïch J, Aguilar J (November 1991).“Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice”British Journal of Pharmacology 104(3): 575–8. doi:10.1111/j.1476-5381.1991.tb12471.x.PMC 1908237PMID 1839138.
9. “Supplement naturally boosts ageing brain power”Sydney Morning Herald. 2008-02-25. Retrieved 2009-07-28.
10. Silveri MM, Dikan J, Ross AJ, et al. (November 2008). “Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy”. NMR in Biomedicine 21 (10): 1066–75.doi:10.1002/nbm.1281PMID 18816480